The Immortal Life of Henrietta Lacks

Henrietta Lacks (August 18, 1920, to October 4, 1951) was a poor Southern African-American tobacco farmer whose cancerous cervical tumor was the source of cells George Otto Gey at Johns Hopkins in Baltimore, Maryland, cultured. These “immortal” cells remain “alive,” 60 years after her death, revolutionizing medical research. In her 2010 book, The Immortal Life of Henrietta Lacks, Rebecca Skloot documents the histories of both the cell line—called the HeLa cell line after the first two letters of her first and last names to protect her identity—and the Lacks family. Henrietta’s husband, David Lacks, was told little following her death. Suspicions fueled by racial issues prevalent in the South at the time were compounded by issues of class and education. Members of the Lacks family were kept in the dark about the existence of the tissue line, and when its existence was revealed in a 1976 Rolling Stone article by Michael Rogers, family members were confused about how Henrietta’s cells could have been taken without consent and how they could still be alive 25 years after her death. Skloot’s book takes the reader on an incredible journey from the “colored” ward of Johns Hopkins Hospital in the 1950s to the research laboratories with freezers full of HeLa cells, to Henrietta’s small, dying town of Clover, Virginia, to east Baltimore, where Henrietta’s children and grandchildren live. The basic facts about the story of Henrietta Lacks are well documented. On February 1, 1951, Ms. Lacks visited Johns Hopkins because of a painful “knot” in her cervix and bloody vaginal discharge. After a biopsy, she was diagnosed with cervical cancer. The appearance of the tumor was unlike anything the examining gynecologist, Dr. Howard Jones, had seen. Prior to the treatment for the carcinoma, cells from the tumor were removed for research purposes without her knowledge or permission, which was standard procedure at that time. During her second visit eight days later, Dr. George Otto Gey obtained another sample of her tumor. These cells would eventually become the HeLa immortal cell line. In significant pain and without improvement, Lacks returned to Johns Hopkins Hospital on August 8 demanding admission and remained there until her death on October 4 at the age of 31. A subsequent partial autopsy showed that the cancer had metastasized throughout her body. Gey “discovered that [Henrietta’s] cells did something they had never seen before: They could be kept alive and grow.” (p. 94) Cells obtained previously from other sources would survive for only a few days. Some cells in Lacks’ tissue sample behaved differently than others. Gey was able to isolate one specific cell, multiply it and start the HeLa cell line. As the first human cells that could be grown in a lab and were “immortal” (did not die after a few cell divisions), they could then be used for many experiments. This represented an enormous boon to medical and biological research. It is estimated that total weight of all the HeLa cells ever grown exceeds 50 million metric tons. The HeLa cells were vital for developing the polio vaccine and uncovering secrets of cancer, viruses and radiation effects. These cells led to improvements in in vitro fertilization, cloning, and gene mapping. Demand for the HeLa cells quickly grew. A special unit was established in Tuskegee Institute, Tuskeegee, Alabama, where African-American scientists helped grow the HeLa cells and also evaluated Dr. Jonas Salks’s polio vaccine. “Black scientists and technicians, many of them women, used cells from a black woman to help save the lives of millions of Americans, most of them white. And they did so on the same campus—and at the very same time—that state officials were conducting the infamous Tuskegee syphilis study.” (p. 97) In 1932, 600 African-Americans, 399 with syphilis and 201 without, were enrolled in a study to investigate the natural course of syphilis. In 1947 penicillin was discovered as the drug of choice for syphilis, but the study patients were denied it. This federal government-sponsored study was projected to last six months, however, it continued for 40 years and was Book Review